SAFC yesterday announced the roll-out of a new, ‘ready-to-use’ solution-based biocide, ProClin® B-119 (www.safcglobal.com/proclin). This safe and effective biocide has been specifically designed for challenging formulation conditions and works across pH levels 4-12 and at temperatures of up to 90 degrees centigrade to control microorganisms, providing stability and reliability of in-vitro Diagnostics (IVD) reagents used in medical testing. ProClin B-119 is formaldehyde-free and has been specifically designed to meet a wider range of pH levels and temperatures than biocides currently on the market.
“ProClin B-119 is valuable for R&D scientists looking for a robust biocide that is safe, efficient and effective for their diagnostics research,” said George Crowell, SAFC’s Diagnostics Segment Manager. “This addition, offered exclusively through SAFC, extends the Company’s diverse product portfolio for the rapidly expanding medical diagnostics market, providing single-point access to a broad range of regulatory compliant and custom manufactured raw materials.”
Combining technical and industrial expertise, SAFC provides customers security of supply with over 100,000 raw materials, of which 48,000 are produced in-house, along with the capability of providing customized manufacturing, packaging and comprehensive analytical services.
Key Features of ProClin Preservatives
- Compatibility with key enzymes and assay indicators
- Will not inhibit antibody binding
- Easy-to-use water-soluble liquid, effective at very low concentrations
- Excellent stability over a wide pH range
- Level of active ingredients assayable by HPLC (Inquire for a HPLC standard)
- At recommended usage levels, ProClin presents no health hazards, toxological problems or disposal issue
Mechanism of Action
- The active components of ProClin are three isothiazolones, 2-Methyl-4-isothiazolin-3-one, 5-Chloro-2-methyl-4-isothiazolin-3-one and 1,2-Benzisothiazolin-3-one
- Within minutes of contacting a microorganism, the active components penetrate the cell wall and inhibit specific enzymes (at the points noted in red in the Krebs Cycle, shown below.)
- Growth, macromolecule synthesis and respiration are inhibited, ultimately leading to cell death.
Full details of SAFC’s ProClin offering can be access online here.
