Following the introduction of the CHO cell line earlier this year in July, SAFC has just announced the release of a novel CHOZN® GS-/- Zinc Finger Nuclease (ZFN)- modified Chinese Hamster Ovary (CHO) cell line. Designed for use in the production of biopharmaceuticals, the new CHOZN GS-/- cell line is the first commercially available glutamine synthetase (GS) knockout CHO cell line proven to shorten bioproduction times in early development, enabling customers to enhance their speed-to-market and increase cost efficiency. Read more about it on Manufacturing Chemist by clicking here.
Archive for the ‘ZFN’ Category
LIVE from CPhI Worldwide: SAFC Announces Introduction of CHOZN GS Knockout CHO Line
Thursday, October 27th, 2011Pharma Magazine Feature: From DNA to Harvest: A Platform Approach to Improved Bio-Production
Wednesday, September 28th, 2011The September/October issue of Pharma Magazine features an article authored by Bruce Lehr, SAFC Director of Development and Kevin Kayser, SAFC Associate Director of Cell Engineering which discusses using a platform development and manufacturing strategy to control operations across biopharmaceutical projects. The article further discusses SAFC’s ZFN (Zinc Finger Nuclease) technology which allows for the isolation of genes for modification. Please take a moment to read the full story here.
The Launch of the CHOZN Cell Line: Where it Came from and Where it is Going
Thursday, July 7th, 2011
Kevin Kayser, SAFC Associate Director Cell Sciences and Development
As the launch of the first CHOZN® cell line is announced, we talk to SAFC’s Associate Director Cell Sciences and Development, Kevin Kayser, about the cells, what they can do, and what’s to come in the future.
News Alert: SAFC Extends Gene Editing Technology Platform with Readily-Available Zinc Finger Nuclease Products and Services
Wednesday, November 10th, 2010SAFC today announced an extension to Sigma-Aldrich’s proprietary CompoZr® Zinc Finger Nuclease (ZFN) platform that will expand the availability of ZFN-based technology to include off-the-shelf ZFNs and custom cell engineering services for use in the biopharmaceutical industry.
Life Science Leader: Zinc Fingers Point The Way Forwards
Wednesday, September 29th, 2010In October’s issue of Life Science Leader, Kevin Kayser, manager of the Cell Culture Engineering group at SAFC, gives an overview of Zinc Finger Nuclease (ZFN) technology, an area that has, since its introduction, helped facilitate rapid advances within the field of targeted genome editing.
ZFNs are custom-engineered fusion proteins that bind DNA in a targeted way to create double-stranded breaks at precise points, enabling the genome to be edited. Modifications, insertions or deletions can be made to the genome, a development that facilitates the rapid creation of genetically modified cell lines that give greater insight into genetic diseases and their associated pathway biologies. Such knowledge can be potentially used to develop therapeutic treatments for all manner of diseases and conditions that have identified genetic markers.
Sartorius Stedim Biotech and SAFC Announce ‘Modern Challenges on Cell Culture Processes’ Seminar
Friday, April 16th, 2010Sartorius Stedim Biotech and SAFC today announced details of a co-hosted one-day seminar, titled ‘Modern Challenges on Cell Culture Processes,’ which will be held on Tuesday May 11 in Basel, Switzerland at the Grand Hotel Les Trois Rois.
The seminar program covers some of latest technologies and ‘hot button’ topics relating to cell line development, media cultivation and optimization, and includes keynote sessions on:
- Cell Line Engineering using Zinc Finger Nucleases (ZFNs), presented by Dr. Heike Lehrmann – Tactical Marketing Specialist, Sigma-Aldrich
- Developments to Increase Consistency in Cell Culture Media, presented by Hikmat Bushnaq-Josting – Technical Manager, Europe, SAFC
- Combined Use of Sartorius Stedim Biotech’s Sensolux® with the CERTOMAT® CTplus: new tools for media optimization and seed train cultivation, presented by Dr. Wolfgang Asche – Sartorius Stedim Biotech
- Managing the Disposable Concept at an Industrial Scale, presented by Ralph Kretzschmar – Field Marketing Manager, Sartorius Stedim Biotech
- Increasing Process Efficiency Utilising Disposables in Downstream Processing Ray Baldwin – Technical Manager, Packaging & Delivery Systems, SAFC
In addition, there will a lunchtime networking session and Q&A forum. Places are limited and registration closes on May 7th. Further information, a full schedule and registration details can be found here.
SAFC Proceeds With Technology-Based Growth
Saturday, January 9th, 2010“The custom manufacturer and fine-chemicals company adds further capabilities in high-potency and viral-product manufacturing and targets synergies in gene editing with its parent company, Sigma-Aldrich.”
Great article by Patricia van Arnum for Pharmaceutical Technology that looks at how Sigma-Aldrich and SAFC are “leveraging their slate of technology-based capabilities as part of their growth strategy.” The article covers antibody drug conjugation and high-potency manufacturing, viral-product manufacturing and how Zinc Finger Nuclease technology is being used to develop cell lines in the company’s viral-product manufacturing business and the development of media.
