SAFC Marketing Manager, Nick Johnson, talks about what SAFC is bringing to the “Big Easy” in 2012 and why Informex is a key annual event for SAFC. Please click here to read the full blog.
Archive for the ‘Solid State Chemistry’ Category
SAFC Featured in the Informex 2012 Blog
Friday, January 27th, 2012SAFC Gets Ready to Take on the “Big Easy” at Informex 2012!
Tuesday, January 24th, 2012SAFC wasted no time moving forward in 2012! As we ramp up for our first big show of the year, Informex 2012, we wanted to take some time to run through what we will have to offer leading up to and throughout the upcoming event in New Orleans, LA.
SAFC’s Tom Beil talks Rx360 in Pharma magazine….
Wednesday, April 6th, 2011In the latest issue of Pharma magazine http://www.pharma-mag.com/, Tom Beil, VP of Quality & Regulatory Affairs at SAFC talks about “A Matter of Trust” and looks at the Rx360 consortium and its mission to “create and monitor a global quality system that meets industry and regulators’ expectations, and to ensure patient safety by guaranteeing product quality and authenticity at every stage of the supply chain.” The article gives an excellent overview of the work that Rx360 does, and the potential benefits for the pharma industry and ultimately, patients. You can read the full article here.
Could TSC determination be the technique of choice for routine amorphous analysis?
Tuesday, October 19th, 2010An amorphous substance is less stable than its crystalline counterpart. In the pharmaceutical industry the effects of even relatively small amounts of amorphous material can significantly affect a drug’s behaviour e.g. dissolution rate, chemical stability.
For this reason, it is necessary to evaluate and ideally quantify the amorphous component within a pharmaceutical product. Current techniques do not measure directly the amount of either crystalline or amorphous material. Rather the techniques rely on chemically pure highly crystalline or pure amorphous reference materials e.g. Xray Powder Diffraction, changes in either component as a consequence of some physical stimulus e.g. exposure to humidity.
Typically limits of detection maybe of the order of 1-5% for the most suitable materials and more likely 5-10%. Indeed the amorphous quantification of a given material is not empirical.
A more recent technique TSC (thermally stimulated current) spectroscopy may offer much lower levels of detection <1%, a wider range of materials application and an empirical approach to amorphous quantification.
Could this be the technique of choice for routine amorphous analysis?
Co-crystal Case Study
Wednesday, February 17th, 2010In order to turn an API into a successful pharmaceutical product, having a suitable crystal form of the molecule available is critical. This can often present significant hurdles that must be overcome. Here SAFC looks at how cocrystallization offers potential solutions to improve the stability of APIs and provide drug formulators with another potential tool to overcome the problems that arise when an API has solubility issues.
Solid-State Chemistry: A Technical Forum
Thursday, February 4th, 2010Pharmaceutical Technology’s Patricia van Arnum talks to leading experts in the Solid State chemistry space, including Professor Chris Frampton, chief scientific officer of SAFC Pharma’s Pharmorphix Solid State Services, who share their insights into polymorphism and crystallization.
SAFC Pharma’s adds the industry’s first commercial dual wavelength X-ray diffractometer to support it’s Pharmorphix Solid State Chemistry Services
Thursday, October 15th, 2009ST. LOUIS, MO. October 13, 2009 – SAFC Pharma® today announced that its Pharmorphix® Solid State Research Laboratories in Cambridge, UK, have installed a new single crystal X-ray diffraction system. The Oxford Diffraction SuperNovaTM system, which can determine the crystal structures from the most challenging crystal samples, is the first industrial installation of this state-of-the-art instrumentation anywhere in the world.
Full press release available on SAFC Pharma website here
