In the May issue of the fine British publication Speciality Chemicals, Dolores Shaw of Dow Chemical and SAFC’s Duane Flom feature in a article that looks at the IVD industry and the vital role, from an environmental standpoint, of biocides in protecting diagnostic reagents against microbial contamination. Effective protection through the use of biocides is critical in maintaining the integrity of these reagents, which helps to ensure that the diagnostics process is robust and the possibility serious failures such as misdiagnosis are minimized.
Archive for the ‘Diagnostics’ Category
Speciality Chemicals: Preservatives for the IVD industry
Tuesday, June 7th, 2011SAFC In-Depth: Point of Care Testing and Diagnostics Technology
Tuesday, May 24th, 2011Following the recent announcement of the launch of raw materials and custom services that SAFC has developed specifically for the Point of Care (POC) testing and diagnostics market, SAFC Live caught up with George Crowell, SAFC Diagnostics Segment Manager, to talk more about SAFC’s offering, current market trends and how the market is expected to evolve in the coming years.
SAFC® Announces Launch of Raw Materials and Custom Services Developed Specifically for Point-of-Care Diagnostics Manufacture
Tuesday, March 15th, 2011ST. LOUIS, MO. – March 15, 2011 – SAFC®, a member of the Sigma-Aldrich® Group (NASDAQ: SIAL), today announced the launch of a diverse product offer designed to meet the demands of the burgeoning Point-of-Care (POC) testing diagnostics market. The offer provides a wide range of raw materials and custom manufacturing services for producers of both self test, or Over-the-Counter (OTC), diagnostic kits as well as professional POC diagnostics. (more…)
SAFC introduces environmentally-safe broad spectrum biocide for medical IVD SAFC introduces environmentally-safe broad spectrum biocide for medical IVD apps
Thursday, June 17th, 2010SAFC yesterday announced the roll-out of a new, ‘ready-to-use’ solution-based biocide, ProClin® B-119 (www.safcglobal.com/proclin). This safe and effective biocide has been specifically designed for challenging formulation conditions and works across pH levels 4-12 and at temperatures of up to 90 degrees centigrade to control microorganisms, providing stability and reliability of in-vitro Diagnostics (IVD) reagents used in medical testing. ProClin B-119 is formaldehyde-free and has been specifically designed to meet a wider range of pH levels and temperatures than biocides currently on the market.
“ProClin B-119 is valuable for R&D scientists looking for a robust biocide that is safe, efficient and effective for their diagnostics research,” said George Crowell, SAFC’s Diagnostics Segment Manager. “This addition, offered exclusively through SAFC, extends the Company’s diverse product portfolio for the rapidly expanding medical diagnostics market, providing single-point access to a broad range of regulatory compliant and custom manufactured raw materials.”
Combining technical and industrial expertise, SAFC provides customers security of supply with over 100,000 raw materials, of which 48,000 are produced in-house, along with the capability of providing customized manufacturing, packaging and comprehensive analytical services.
Key Features of ProClin Preservatives
- Compatibility with key enzymes and assay indicators
- Will not inhibit antibody binding
- Easy-to-use water-soluble liquid, effective at very low concentrations
- Excellent stability over a wide pH range
- Level of active ingredients assayable by HPLC (Inquire for a HPLC standard)
- At recommended usage levels, ProClin presents no health hazards, toxological problems or disposal issue
Mechanism of Action
- The active components of ProClin are three isothiazolones, 2-Methyl-4-isothiazolin-3-one, 5-Chloro-2-methyl-4-isothiazolin-3-one and 1,2-Benzisothiazolin-3-one
- Within minutes of contacting a microorganism, the active components penetrate the cell wall and inhibit specific enzymes (at the points noted in red in the Krebs Cycle, shown below.)
- Growth, macromolecule synthesis and respiration are inhibited, ultimately leading to cell death.
Full details of SAFC’s ProClin offering can be access online here.
